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ba0003oc1.2 | Phosphate metabolism, fracture repair and osteoarthritis | ECTS2014

Study of Hyp or Phex null male fetuses reveals that eightfold increased FGF23 does not alter fetal–placental phosphorus homeostasis or prenatal bone formation and mineralization

Ma Yue , Kirby Beth J. , Kovacs Christopher S.

Fibroblast growth factor-23 (FGF23) controls serum phosphorus by acting on the kidneys to excrete phosphorus and reduce calcitriol. These actions are well established in adults and children, but whether FGF23 regulates fetal phosphorus metabolism is unknown. We used X-linked Hyp or Phex null male fetuses to study the effect of excess FGF23 on fetal phosphorus metabolism. Phex+/− females and WT males were mated to generate WT, Phe...

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Study of Hyp or Phex null male fetuses reveals that eightfold increased FGF23 does not alter fetal–placental phosphorus homeostasis or prenatal bone formation and mineralization

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